Background: Multi-organ dysfunction syndrome (MODS) is a life-threatening condition where two or more organs in the body fail to function properly. WHO classifies triglyceride levels as mild (<200 mg/dL), moderate (200–500 mg/dL), and severe (>500 mg/dL). Aim and objectives: Aim: The Aim of the study is to study and access clinical correlates of triglyceride levels and multi organ dysfunction in adults Results: Among the 316participants, 55% of individuals had normal triglyceride levels, 23% had mild elevation, and 22% had moderate elevation. Among the conditions studied, hyperlipidemia, hypertension (HTN), hyperthyroidism, and metabolic-associated steatotic liver disease (MASLD) showed statistically significant associations with elevated triglyceride levels, with p-values of 0.011, 0.037, 0.001, and 0.015, respectively. Total cholesterol (r = 0.4530), LDL (r = 0.377), VLDL (r = 0.48), and the cholesterol: HDL ratio (r = 0.307), all with p-values < 0.001 indicates significant positive correlation of triglycerides. Conclusion: In conclusion, the study highlights a significant association between elevated triglyceride levels and conditions such as obesity, alcohol use, smoking, diabetes, hypertension, hyperlipidemia, hyperthyroidism, and MASLD. Elevated triglyceride levels are closely linked to increased risk of multi-organ dysfunction and related comorbidities.