This research investigates the systematic adaptation of tuberculosis prevention educational programs to regional epidemiological, sociocultural, and healthcare infrastructure characteristics. The study employs community-based participatory frameworks integrating local health determinants with evidence-based prevention strategies, demonstrating enhanced program effectiveness through culturally responsive intervention design and significant improvements in community engagement and preventive behavior adoption rates. Keywords: regional adaptation, cultural competence, community-based intervention, health literacy, epidemiological determinants, preventive behavior, healthcare accessibility, population health, implementation science