Abstract: Stroke remains one of the leading causes of long-term disability worldwide, profoundly affecting survivors' physical, psychological, social, and spiritual well-being. Beyond the physiological aftermath, stroke survivors face multidimensional challenges that diminish their quality of life (QoL). Nurses play a pivotal role in promoting recovery and adaptation through holistic, person-centered care that addresses biological, emotional, and social domains. This review explores the determinants influencing quality of life in stroke survivors and examines evidence-based nursing strategies that contribute to optimal rehabilitation outcomes. By emphasizing holistic nursing interventions—including physical rehabilitation, psychological support, patient education, and family involvement—this paper highlights the comprehensive role of nurses in improving the lived experiences of stroke survivors. Furthermore, it underscores the necessity for continued nursing research and policy development to ensure sustainable, high-quality post-stroke care.