Tuberculosis is one of the infectious diseases that remains a global public health challenge, including in Indonesia. Tuberculosis caused by the bacterium Mycobacterium tuberculosis. In high-burden settings, adolescents constitute a significant proportion of both the general population and tuberculosis patients. To determine the profile of adolescent tuberculosis patients in RSUD dr. Soetomo Surabaya from January 2023 to December 2024. This study is conducted using a descriptive retrospective study design using a total sampling technique from medical records. Data on adolescent tuberculosis patients (aged 10–19 years) in RSUD dr. Soetomo Surabaya for the 2023–2024 period included 98 patients, with the majority in the 15–19 age group (60%), while the lowest prevalence was in the 10–14 age group (40%). Female patients outnumbered male patients, accounting for 65% and 35%, respectively. Most patients were diagnosed with pulmonary tuberculosis (53%), while the remaining 47% were diagnosed with extrapulmonary tuberculosis. The majority of adolescents had moderate nutritional status, with 31 patients (31%). The most frequently used specimen for the molecular rapid test was sputum (63%), and the majority of these samples tested positive for TB (63%). A total of 81% of adolescent patients showed abnormalities on CXR. Most adolescent TB patients in Surabaya (2023–2024) were aged 15–19 and female. Pulmonary TB was more common, with moderate nutritional status being typical. Sputum was the most used specimen for testing, with a high positivity rate, and 81% showed chest X-ray abnormalities. These findings highlight the importance of tailored TB approaches for adolescents.