This Book of Abstracts presents the scientific contributions of the 2nd International Conference on Trends and Challenges in Digital Education (DETC 2025), featuring 55 accepted papers, 112 authors, and participation from 21 countries across 3 continents, demonstrating a significant expansion from the previous edition. The conference brings together researchers, educators, policymakers, and innovators to explore how digital transformation is reshaping education systems worldwide. Key themes include: • artificial intelligence in education • digital ethics and responsible innovation • adaptive and hybrid assessment • data analytics and learning analytics • innovative pedagogies and learner-centered models • digital transformation of institutions. Aligned with the European Digital Education Action Plan (2021–2027) and DigiEduHack, DETC 2025 emphasizes collaboration, evidence-based practice, and inclusive innovation. This volume reflects the growing global relevance of digital education research and the commitment of the international academic community to co-create sustainable, accessible, and human-centric learning solutions.