This white paper maps an orderly shift from diagnostic views of complexity to generative design, aligned with a 5.0 stance that treats complexity as a design space for the common good. It starts from SPOD—a stable, deterministic world—then passes through VUCA, TUNA, RUPT, and BANI, partial lenses that surface volatility, turbulence, paradox, fragility, and nonlinearity. At the core is F.L.I.P., a threshold model turning fragilities, limits, incoherences, and paradoxes into learnable information. On that threshold stands S.P.I.A³: a spatial, polycentric, intelligent frame, strengthened by three A’s—Anticipatory, Ambidextrous, Antifragile—that stabilize trajectories and enable self-adaptive, regenerative behavior. Innovation, the article argues, is not spontaneous but a governed process with roles, criteria, and measures for traceability and reproducibility. The paper closes with implications for governance, lightweight operational architectures, essential metrics, and guidance for cities and communities, critical infrastructures, innovation ecosystems, and compliance, oriented to shared value.