Rheumatoid arthritis is an autoimmune disease which causes systemic complications, disability and even death. Its pathophysiology involves chronic inflammation of synovial membrane. New molecules in the biologic pathway have been discovered and are considered new target for experiments. In this experiment 100 flavonoids showing anti-inflammatory activities in different studies were evaluated using in silico approach to get the best possible lead. Orientin (IFD score: 640.28) and leucocyanidin (IFD score: 638.22) showed highest binding affinity with protein 4K6Z, while vitexin (IFD score: 622.21) and hyperoside (IFD score: 623.55) showed highest binding affinity with protein 4G1W among the set of flavonoids taken. To support the results of this investigation, leucocyanidin and orientin could be investigated further for the treatment of rheumatoid arthritis through both in vitro and in vivo experiments. Keywords Rheumatoid arthritis; Induced fit docking; Anti-inflammatory; Flavonoids; In silico