Poster abstract for ELIXIR UK All Hands meeting, Exeter 23 Oct 2025 The IUPHAR/BPS Guide to Pharmacology (GtoPdb; www.guidetopharmacology.org, PMID: 3789734) is an open-access, expert-curated, FAIR-compliant (Findable, Accessible, Interoperable, Reusable) online database of pharmacological targets and the substances that act on them. Its reputation for quality is recognised by a Hidden REF award and selection as both an ELIXIR-UK and Global Core Biodata Resource. We continue to expand connectivity of our curated entities to external resources in other quality databases. These consequently offer an expanding range of powerful navigation and data mining options across chemical structures, sequences and documents that users may not be aware of but will be outlined here. Of the 12,744 GtoPdb substances 10565 form CIDs that are connected by identity, extensive annotations and similarity neighbours within the vast PubChem system. Useful intersects include 86% BioAssay results, 83% to patent documents, 23% to PDB entries and 82% vendor offerings. Our expanding SID tags retrieve 1995 approved drugs, 393 clinical antibodies, 136 entries to the Guide to Malaria Pharmacology (GtoMPdb), 1477 from Guide to Immunopharmacology (GtoImmuPdb), 561 antibacterials and 355 natural products. For literature connectivity NCBI LinkOut includes 33,093 GtoPdb-indexed PubMed IDs. Of these 8,418 are indexed in EPMC. The GtoPdb chemistry-to-target cross-references in UniProt are up to 2,272 sequences including Human (1,647), Rat (323) and Mouse (278). In conclusion GtoPdb provides users with expanding connectivity out to the pharmacology informatics ecosystem. While querying and navigating between ligands, documents and targets is complex the ability to “slice-dice-and-compare” across these key entities is powerful and provides unique insights. (this is similar in title and content to a poster presemted at the British Pharmacological Society, Harrogate, Dec 2024)