Motor tics in Tourette Syndrome (TS) frequently lead to significant musculoskeletal pain, driven by the repetitive strain placed on joints and muscles. Conventional treatments, including pharmacologic and behavioral approaches, often fail to provide sufficient pain relief or come with adverse side effects. This case report explores the application of osteopathic manipulative treatment (OMT) as a targeted solution for tic-induced pain. Through the use of OMT, an 18-year-old female with refractory TS-associated tic pain achieved notable symptom relief, with techniques addressing both localized muscle dysfunction and systemic autonomic regulation. This case demonstrates the possible therapeutic utility of OMT in this patient population and also highlights the importance of fostering innovation within osteopathic education. Further research should explore OMT’s efficacy in treating TS-associated motor tic pain as well as enhance osteopathic training programs to foster curiosity and adaptable applications of OMT across diverse disease pathologies.