The Nigerian Civil War (1967–1970) left deep political, economic, and psychological scars on the Igbo people of southeastern Nigeria. The phrase “In Biafra, Africa Died” captures the magnitude of human and moral tragedy that accompanied the conflict, as well as the enduring marginalization that followed. This study examines the politics and economics of Igbo exclusion in post-war Nigeria, focusing on how state policies, resource allocation, and federal structures perpetuated socio-economic inequality and political disempowerment. It explores the impact of post-war reconstruction measures such as the “Twenty Pounds Policy,” abandoned property decrees, and deliberate industrial neglect on the Igbo economy. Politically, it interrogates the systematic underrepresentation of the Igbo in national decision-making processes and federal appointments. Using a political economy framework, the study argues that the post-war Nigerian state institutionalized structures of exclusion that constrained Igbo reintegration and development. It concludes that overcoming these historical injustices requires genuine federal reforms, equitable economic policies, and national reconciliation that recognizes the Igbo struggle as integral to Nigeria’s democratic and developmental aspirations.