Abstract: Dairy products are highly perishable and susceptible to microbial spoilage, chemical degradation, and quality loss during storage and distribution. Traditional packaging technologies often fail to adequately protect these products from environmental stressors such as oxygen, moisture, and microbial contamination. Recent advances in nanotechnology-based smart packaging offer innovative solutions to extend shelf life, preserve nutritional integrity, and ensure consumer safety. Smart packaging systems, incorporating nanomaterials such as silver nanoparticles, titanium dioxide, and nanoclays, provide enhanced barrier properties, antimicrobial functions, and active monitoring of product quality. In addition, nanosensors embedded in packaging materials allow real-time detection of spoilage indicators, enabling rapid decision-making across the supply chain. These innovations not only reduce post-harvest losses but also contribute to food quality assurance and regulatory compliance. This review explores the current state of nanotechnology applications in smart dairy packaging, highlighting their mechanisms, benefits, and potential risks. It also addresses sustainability challenges associated with nanomaterials, consumer acceptance, and regulatory frameworks that govern their safe usage. By critically examining both technological advancements and implementation barriers, this paper provides a comprehensive perspective on how nanotechnology-driven smart packaging can revolutionize the dairy industry. The discussion emphasizes the importance of multidisciplinary collaboration between food scientists, material engineers, and policymakers to ensure sustainable adoption and maximize societal benefits. Keywords: Nanotechnology; Smart Packaging; Dairy Shelf Life; Food Quality Assurance; Nanosensors. Title: Investigating Nanotechnology-Based Smart Packaging for Extending Dairy Product Shelf Life and Improving Food Quality Assurance Author: Felix Donkor, Mavis Nkem Okafor, Joy Onma Enyejo International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 13, Issue 2, October 2025 - March 2026 Page No: 17-34 Research Publish Journals Website: www.researchpublish.com Published Date: 28-October-2025 DOI: https://doi.org/10.5281/zenodo.17381311 Paper Download Link (Source) https://www.researchpublish.com/papers/investigating-nanotechnology-based-smart-packaging-for-extending-dairy-product-shelf-life-and-improving-food-quality-assurance