EOSC-ENTRUST aims to create a European network of Trusted Research Environments (TREs) for sensitive data and drive European interoperability between TREs by development of a common blueprint for federated data access and analysis. The project is supported by four driver projects (hereafter Drivers), i.e. use cases which are prototypic for federated, multinational use of TREs in research practice across scientific domains and user communities: Federated Human Genomics as a catalyst for European TRE provision (EMBL, CRG, BSC, CSC) Common standards to enable trans-national sharing of administrative and social science data (CESSDA, GESIS, UKDS, TARKI) Enabling the re-use of clinical trials data for research purposes across Europe (ECRIN, UiO, HDR UK, UNIVDUN) Public-Private interactions between TRE in health and environmental data (Turku UAS, CSC, Sigma2)