Background: Globally, dengue fever, a virus spread by mosquitoes, is a serious public health concern. Changes in hematocrit level and platelet count, in particular, are important markers of the severity of the disease. Objective: The purpose of this prospective observational study was to clarify the connection between dengue fever patients' hematocrit level and platelet count and investigate the potential consequences for managing and predicting the illness. Methods: A total 80 dengue patients were gathered from a tertiary care hospital. Statistical models were used to analyze and correlate the hematological parameters, such as hematocrit level and platelet count, with dengue severity. Results: In dengue patients, the study found a statistically significant correlation between platelet count and hematocrit level. Its prognostic value was highlighted by the noteworthy correlation between NS1Ag positivity and thrombocytopenia as well as PCV changes. Conclusion: This study emphasizes how crucial it is to track platelet count and hematocrit level in order to identify severe dengue early. The results have important ramifications for clinical practice, emphasizing the necessity of prompt action and effective patient care to reduce dengue fever-related morbidity and mortality.