Background, aims and objectives: COPD is one of the leading cause of mortality and morbidity worldwide. It shows a decline in the lung function followed by impairment of physical functions. Quality of life is an important factor for measuring the impact of COPD in the patient from socializing and enjoying their hobbies.This study aimed at assessing the health related improvement in the quality of life of COPD patients. Materials and methods: A hospital-based prospective study was conducted in a tertiary care hospital, Kerala, India to assess the quality of life in 100 COPD patients for a period of 6 months by using St. George respiratory Questionnaire(SGRQ). Demographic details, therapy related factors and smoking status were collected. Result: In our analysis of 100 COPD patients, at the baseline assessment, the average SGRQ score was 59.92, with a standard deviation of 16.77. Conversely, during the follow-up period, there was a decrease in the mean score to 36.17, with a standard deviation of 14.23, indicating a decline in the SGRQ score over time. Lower SGRQ scores indicated better respiratory health and fewer symptoms. Conclusion: The results from our study revealed an improved quality of life among COPD patients significantly over time. The change in the mean SGRQ (St. George's Respiratory Questionnaire) score from 59.92 to 36.17 indicates an improvement in respiratory health or quality of life among the population being studied. When individuals adhere more closely to their medication regimens, they are more likely to manage their condition effectively, leading to better health outcomes and an enhanced quality of life.