Open science is a set of principles and practices to make scientific research available and accessible to everyone. This deliverable aims to explore and operationalise open science principles and practices that can support the research activities of the TRANSIENCE project. First, the report summarises the main activities and outputs of TRANSIENCE and matches them with relevant open science principles. Specifically, all research activities of the project will be described through open-access publications (deliverable reports, scientific journal papers, etc.). All input and output datasets developed in TRANSIENCE will be shared based on the FAIR principles for enabling findable, accessible, interoperable, and reusable data. Model code as well as relevant scripts (e.g., for data processing) will be shared as open source, while both code and data will be deposited in online repositories that follow the TRUST (Transparency, Responsibility, User focus, Sustainability, and Technology) principles. Since modelling activities play a major role in TRANSIENCE, the report provides more details on open science practices that can support modelling. Specifically, the report presents open science protocols to guide major research activities related to model development, linking, and use. Subsequently, the report delves further into practices that support the exchange of model data by introducing the concept of ontologies and providing a hands-on example of applying ontologies in the modelling data of TRANSIENCE. The open science protocols and ontologies will be further updated later in the project based on the feedback and experience of the modelling partners.