Introduction: Gestational Diabetes Mellitus (GDM) is defined as carbohydrate intolerance first recognized during pregnancy, irrespective of the treatment with diet or insulin. High blood sugar during pregnancy poses risks to both the mother and fetus, necessitating effective screening and management. DIPSI Recommends a non-fasting 75g oral glucose challenge test, diagnosing GDM if 2hour blood glucose is ≥ 140 mg/dl. This costeffective single step approach enhances screening accessibility, particularly in resource limited settings. Methodology: A prospective observational study evaluated the efficacy of DIPSI guidelines in screening of GDM and assessing maternal-fetal outcome. Results: The incidence of GDM in our study was 9.6 % by using 75 gm OGTT (DIPSI) and 7% by using standard 100 gm OGTT (Carpenter and Coustan). Most cases were in age group 25 to 29 years (30.8%). Higher gravidity (gravida ≥3, 12.5%) and BMI ≥30kg/m2 (50% positive) correlated with GDM risk. Family history of diabetes increased positivity (23.3%). Maternal complication included gestational hypertension (56.3%) and polyhydramnios (43.8%). Among 23 DIPSI positive cases 95.6% had LSCS and 4.4% had vaginal delivery. Respiratory Distress was the most common neonatal complications among the subjects, followed by hyperbilirubinaemia and hypoglycaemia. Conclusions: DIPSI, single step OGTT is economical, feasible and tailored for Indian populations, improving early detection and reducing complications. Its simplicity enhances compliance, making it crucial for GDM management in diverse healthcare settings.