Background: Sleep is vital for brain development, body healing, production of repair molecules, and long-term memory formation. Poor sleep quality in adolescents can lead to psychological problems such as depression, stress, and anxiety, which can negatively affect daily life and academic performance. Addressing these issues is essential to ensure optimal sleep quality for optimal brain function. Aim: The purpose of this study was to investigate the relationship between sleep patterns and mental health in adolescents. Method: A cross-sectional study was conducted, measuring sleep quality with PSQI and stress, anxiety, and depression with the DASS-Y questionnaire among 350 students from different middle colleges and private schools. Results: A study found that 13-15 year old have a higher prevalence of poor sleep (83%) while 16-18 year old have more balanced sleep (51% poor, 49% good). Nearly half of the 350 participants experienced poor sleep quality, with stress, anxiety, and depression being the most common. The study found a significant relationship between sleep quality and (mental health). Conclusion: Sleep deprivation increases mental illness vulnerability, highlighting the need for healthy sleep habits. Clinical pharmacists collaborate with medical professionals to improve adolescents' physical and psychological health through techniques and counseling, promoting good sleep habits.