The intersection of edge artificial intelligence (AI), autonomous systems, robotics, and sensor fusion in perception and navigation advances the development of last-mile delivery autonomous vehicle (AV) platforms that evolve towards software-defined and AI-defined vehicles (SDVs and ADVs). The advancements include multiple sensor systems for perception and communication (e.g., ultrasound, inertial, LiDAR, radar, camera, V2X, etc.), real-time data processing for localisation, and robust algorithms for navigation and interaction with diverse traffic environments. This chapter presents the concept and the implementation of an AI-based perception and sensor fusion platform technical solution for autonomous last-mile delivery in controlled traffic environments.