Abstract Burn injuries in children represent a significant clinical challenge due to their unique anatomical and physiological characteristics, including thinner skin, higher risk of fluid imbalance, and greater susceptibility to infection and scarring. Effective wound management is crucial to promote rapid healing, minimize pain, prevent complications, and improve long-term functional and aesthetic outcomes. Among the various dressing methods, amniotic membrane (AM) has emerged as a promising biological dressing due to its rich extracellular matrix, growth factors, anti-inflammatory properties, and immunological safety. This review critically examines the clinical perspectives of AM dressing in comparison to conventional and advanced wound dressings, including silver sulfadiazine, hydrocolloids, and paraffin gauze, in paediatric burn care within tertiary healthcare setups. Key outcomes, including epithelialization rate, infection control, pain reduction, frequency of dressing changes, hospital stay, and scar formation, are analyzed to evaluate the effectiveness and practicality of AM in paediatric populations. The review also addresses challenges related to AM preparation, storage, and application, highlighting gaps in current research and opportunities for future studies. The evidence suggests that AM dressing offers significant advantages in paediatric burn management, particularly in enhancing healing outcomes and patient comfort, and may represent a valuable adjunct or alternative to conventional dressing methods in tertiary care settings. 

Abstract Burn injuries in children represent a significant clinical challenge due to their unique anatomical and physiological characteristics, including thinner skin, higher risk of fluid imbalance, and greater susceptibility to infection and scarring. Effective wound management is crucial to promote rapid healing, minimize pain, prevent complications, and improve long-term functional and aesthetic outcomes. Among the various dressing methods, amniotic membrane (AM) has emerged as a promising biological dressing due to its rich extracellular matrix, growth factors, anti-inflammatory properties, and immunological safety. This review critically examines the clinical perspectives of AM dressing in comparison to conventional and advanced wound dressings, including silver sulfadiazine, hydrocolloids, and paraffin gauze, in paediatric burn care within tertiary healthcare setups. Key outcomes, including epithelialization rate, infection control, pain reduction, frequency of dressing changes, hospital stay, and scar formation, are analyzed to evaluate the effectiveness and practicality of AM in paediatric populations. The review also addresses challenges related to AM preparation, storage, and application, highlighting gaps in current research and opportunities for future studies. The evidence suggests that AM dressing offers significant advantages in paediatric burn management, particularly in enhancing healing outcomes and patient comfort, and may represent a valuable adjunct or alternative to conventional dressing methods in tertiary care settings.