Abstract Introduction: Vitamin D is a secosteroid hormone with pleiotropic actions that extend beyond skeletal homeostasis to immunomodulatory, anti-inflammatory and anti-fibrotic effects—pathways that are highly relevant to chronic liver disease (CLD) of non-cholestaticaetiology, including metabolic dysfunction-associated steatotic liver disease (MASLD/NAFLD), alcohol-related liver disease (ALD) and chronic viral hepatitis. Aims and Objectives: To assay vitamin D in patients with non-cholestatic chronic liver disease and to compare the parameters of liver function test (LFT) with vitamin D levels and correlate the two if possible. Materials and Methods: The present study was a descriptive observational study with cross sectional design. This Study was conducted over 1 year period from the date of approval of protocol at Nadia district hospital, Krishnanagar, West Bengal. Result: In this study of patients with chronic non-cholestatic liver disease, serum vitamin D status was associated with variations in liver function and disease etiology. While age, sex, and BMI did not differ significantly across vitamin D groups, anti-HCV positivity and underlying etiology showed significant associations, with alcohol-related liver disease more common in patients with lower vitamin D levels and NASH predominating in those with sufficient levels. Liver function parameters—including SGOT, SGPT, ALP, GGT, bilirubin, albumin, and globulin—differed significantly among the groups, indicating greater hepatic dysfunction in patients with vitamin D deficiency or insufficiency. Conclusion: This study highlights a significant association between serum vitamin D status and both liver function and disease etiology in patients with chronic non-cholestatic liver disease. Patients with lower vitamin D levels tended to exhibit more pronounced alterations in liver function markers, including elevated liver enzymes and reduced serum albumin, suggesting greater hepatic dysfunction. 

Abstract Introduction: Vitamin D is a secosteroid hormone with pleiotropic actions that extend beyond skeletal homeostasis to immunomodulatory, anti-inflammatory and anti-fibrotic effects—pathways that are highly relevant to chronic liver disease (CLD) of non-cholestaticaetiology, including metabolic dysfunction-associated steatotic liver disease (MASLD/NAFLD), alcohol-related liver disease (ALD) and chronic viral hepatitis. Aims and Objectives: To assay vitamin D in patients with non-cholestatic chronic liver disease and to compare the parameters of liver function test (LFT) with vitamin D levels and correlate the two if possible. Materials and Methods: The present study was a descriptive observational study with cross sectional design. This Study was conducted over 1 year period from the date of approval of protocol at Nadia district hospital, Krishnanagar, West Bengal. Result: In this study of patients with chronic non-cholestatic liver disease, serum vitamin D status was associated with variations in liver function and disease etiology. While age, sex, and BMI did not differ significantly across vitamin D groups, anti-HCV positivity and underlying etiology showed significant associations, with alcohol-related liver disease more common in patients with lower vitamin D levels and NASH predominating in those with sufficient levels. Liver function parameters—including SGOT, SGPT, ALP, GGT, bilirubin, albumin, and globulin—differed significantly among the groups, indicating greater hepatic dysfunction in patients with vitamin D deficiency or insufficiency. Conclusion: This study highlights a significant association between serum vitamin D status and both liver function and disease etiology in patients with chronic non-cholestatic liver disease. Patients with lower vitamin D levels tended to exhibit more pronounced alterations in liver function markers, including elevated liver enzymes and reduced serum albumin, suggesting greater hepatic dysfunction.