This dataset contains the complete results of a cross-sectional descriptive study that evaluated the perception of clinical simulation among undergraduate dentistry students at Universidad Bolivariana del Ecuador. The purpose of the dataset is to provide open-access empirical evidence on students’ satisfaction and perceived usefulness of simulation-based learning as part of preclinical dental education. The data were collected from 281 students enrolled between the first and fifth semesters through a validated questionnaire combining closed-ended Likert-type items and open-ended questions. Quantitative responses include satisfaction scores across multiple dimensions (e.g., skill development, realism, feedback, and motivation), while qualitative responses capture students’ suggestions and perceived limitations of simulation practice. The dataset includes anonymized variables such as semester, gender, satisfaction level, and coded qualitative categories. Data are stored in CSV and XLSX formats with accompanying documentation describing variable definitions, coding procedures, and descriptive statistics. This dataset may support secondary analyses on dental education, simulation methodologies, or pedagogical evaluation in resource-limited contexts.