Background: The right and left human kidneys are both bilateral organs, but they don't always have the same structure and histology. These kinds of differences can have an impact on how the kidneys work, how surgery is done, and how a diagnosis is made. Researchers in Western countries have looked into these kinds of differences a lot, but not so much in South Asia, especially Bangladesh. It is important to know about these changes in structure and histology because chronic kidney disease (CKD) is becoming more common in the area. Objective: The goal of this study was to look at the differences in shape and structure between the right and left human kidneys in different age groups using cadaver samples from Bangladesh. Method and Material: We used purposive sampling to get 100 kidneys (50 right and 50 left) from unclaimed bodies at Dhaka Medical College and did a descriptive cross-sectional study on them. We put the kidneys in 10% formalin and split them into four age groups: 10 to 19 years, 20 to 39 years, 40 to 59 years, and 60 years or older. The goal of this study is to look at the differences in shape and structure between the right and left human kidneys in different age groups, using cadaveric samples from Bangladesh. We did a descriptive cross-sectional study on 100 kidneys (50 right and 50 left) that we got from unclaimed bodies at Dhaka Medical College through purposive sampling. The kidneys were kept in 10% formalin and split into four age groups: 10 to 19 years, 20 to 39 years, 40 to 59 years, and 60 years or older.The concern was taken by all sample. Results: The results of this study could help us learn more about how kidneys age and what that might mean for medical practice. We used microscopy and staining methods to look at morphometric features (weight, length, width, thickness, and volume) and histological features (the number and size of glomeruli per mm²). We looked at the data with ANOVA and unpaired t-tests. Results: The 20–39 age group had the biggest kidneys and the most glomeruli. The number of glomeruli went down a lot as people got older, but their size went up, which could be a sign of compensatory hypertrophy. The left kidney was always bigger than the right in terms of weight, length, and volume. There were statistically significant changes in structure between the right and left kidneys and between age groups. These results show how important it is for the kidneys to be on the same side and how they change shape as we get older. Conclusion: This study shows that the right and left kidneys have very different structures and histologies, and that they get worse with age, especially after age 60. The results give South Asia some important baseline information and show how important it is for nephrologists, surgeons, and transplant surgeons to know about the area's anatomy. In the future, researchers should use molecular imaging and spatial profiling to learn more about the functional implications.