Leadership and corporate culture are highly influential to each other in the corporate world. Effective leadership has developed organizations into new heights such as increased productivity, better quality workforce, higher profitability and so on. In relation to an effective leadership, neuroscience is an effective tool for leaders to manage their organization through the discovery of the human brain and how neurochemicals in the human body drives human behavior. The procurement of such knowledge could aid leaders to cultivate a healthy corporate culture. This paper mainly talks about how neurochemicals in the human body helps leaders to cultivate a healthy corporate culture.