Abstract Importance: Teleoncology—the use of telemedicine technologies in oncology—has emerged as a critical tool in addressing cancer care disparities, particularly among rural, underserved, and resource-limited populations. Despite growing adoption, comprehensive synthesis of its implementation, barriers, and future directions remains limited. Objective: To review the historical evolution, core applications, challenges, and future directions of teleoncology, with emphasis on rural deployment, pharmaceutical industry integration, and implications for equity-based cancer care delivery. Evidence Review: A narrative review was conducted of literature published between January 2005 and March 2024 using PubMed, Scopus, WHO reports, ASCO resources, and policy documents from oncology organizations and government health agencies. Included sources comprised peer-reviewed studies, white papers, program evaluations, and regulatory frameworks. Key themes were synthesized under domains including access to care, remote treatment monitoring, decentralized trials, patient experience, infrastructure, and stakeholder collaboration. Findings: Teleoncology has evolved from early second-opinion consults to comprehensive models including remote diagnosis, virtual tumor boards, remote chemotherapy supervision, and digital navigation tools. Rural implementation in the United States has shown significant benefits including reduced travel burden, improved time-to-treatment, and non-inferior survival rates. Globally, countries such as Australia, India, and Kenya have adopted teleoncology to extend services to remote areas. Major pharmaceutical companies now support teleoncology-enabled decentralized clinical trials, AI-powered symptom tracking, and real-world evidence generation. Key barriers to implementation include infrastructure deficits, inconsistent reimbursement, regulatory misalignment, digital literacy gaps, and ethical concerns about data use. Emerging hybrid care models, equity-centered platform design, and global licensing frameworks are shaping the future landscape.