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Polymer physics view of peripheral chromatin: de Gennes' self-similar carpet

Authors: Sarıyer, Ozan S.; Erbaş, Aykut;

Polymer physics view of peripheral chromatin: de Gennes' self-similar carpet

Abstract

Using scaling arguments to model peripheral chromatin localized near the inner surface of the nuclear envelope (NE) as a flexible polymer chain, we discuss the structural properties of the peripheral chromatin composed of alternating lamin-associated domains (LADs) and inter-LADs. Modeling the attraction of LADs to NE by de Gennes’ self-similar carpet, which treats the chromatin layer as a polymer fractal, explains two major experimental observations: ( i ) The high density of chromatin close to the nuclear periphery decays to a constant density as the distance to the periphery increases. ( ii ) Due to the decreasing mesh size towards the nuclear periphery, the chromatin carpet inside NE excludes molecules ( via non-specific interactions) above a threshold size that depends on the distance from the nuclear periphery.

Country
Turkey
Keywords

steric hindarence, Reveals, Physics, Peripheral chromatin, DNA, Archictecture, polymer physics, Gene, Chromatin, Dynamics, Nucleosomes, Conformations, lamina-associated domains, Heterochromatin, Nuclear lamina interactions, chromatin, LADs, Self-smilar carpet, Polymer, Organization

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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