This article examines the paradigm shift in cloud migration strategies from traditional lift-and-shift approaches to comprehensive cloud-native transformation. Through analysis of architectural patterns, technological components, and organizational considerations, the article presents a holistic framework for understanding and implementing cloud-native infrastructure. The article synthesizes industry best practices and case studies across multiple sectors to identify critical success factors and common challenges in cloud-native adoption. The article investigates how containerization, microservices architecture, and serverless computing collectively enable organizations to achieve improved scalability, operational efficiency, and business agility. The article highlights the importance of organizational culture and skills transformation alongside technical architecture changes, demonstrating that successful cloud-native implementations require alignment between technology strategy and business objectives. This article contributes to the growing body of knowledge on infrastructure modernization by providing both theoretical foundations and practical guidance for organizations at various stages of cloud maturity.