Raw NMR, MS, HPLC, and biological data for the article "Ligand-Directed Site Selective Cysteine Bioconjugation of the KELCH domain of KEAP1 with Hypervalent Iodine Reagents" published in J. Am. Chem. Soc. DOI: https://doi.org/10.1021/jacs.5c13391 The number of the folders either correspond to compounds numbers in the article or the name of the folder is self-describing. All details concerning conditions and equipment for measurements can be found in the supporting information of the article. For convenience, the word file version of the supporting information can be found on the top of the raw data folder.