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ZENODO
Article . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
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Understanding Gout: Mechanism, Clinical Presentation, and Therapeutic Strategies

Authors: Patil Arati S.*, Preeti V. Kulkarni;

Understanding Gout: Mechanism, Clinical Presentation, and Therapeutic Strategies

Abstract

Gout, also known as gouty arthritis, is a chronic inflammatory disease marked by the buildup of monosodium urate crystals in joints as a result of hyperuricemia, or increased serum uric acid levels. Gout, which was formerly thought of as a "disease of kings," is now understood to be a common metabolic ailment that is becoming more commonplace globally, especially as a result of contemporary lifestyle variables like poor food, obesity, and sedentary behavior. The pathogenesis, clinical characteristics, preventative measures, and developing treatment approaches of gouty arthritis are all examined in this review. Uric acid metabolism and the inflammatory cascade brought on by urate crystal deposition are covered in the first section of the review. Risk factors are investigated, including dietary variables, comorbidities like diabetes and hypertension, and genetic predisposition. The article focuses on clinical diagnosis, including symptomatology, test results, and imaging, to distinguish between acute and chronic tophaceous gout. Current treatment options include pharmacological medications like NSAIDs, colchicine, corticosteroids, and uric acid-lowering pharmaceuticals like allopurinol and febuxostat, as well as non-pharmacological strategies including dietary changes, weight management, and hydration. Early intervention and patient education are key preventive treatments, particularly for at-risk populations.

Keywords

Gout, Uric acid, Treatment, Hyperuricemia, Inflammation

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green