Following the trend for the provision of applications over programmable resources distributed across the computing continuum, in this manuscript, we detail a novel meta-orchestration approach for management of such applications. Two main challenges are considered. The first challenge regards the management of Internet of Things (IoT) interoperability and convergence aspects with edge and cloud computing infrastructure. The second challenge regards the development of synergetic orchestration mechanisms that can facilitate the management of distributed applications across multi-cluster infrastructure.