Many plant species containing the substance of medicinal values have yet to be discovered. The therapeutic values of plant lie in certain bioactive compounds that exhibit the specific biological effect on the human body. In most developing countries traditional medicine & medicinal plants widely contributing as a therapeutic agent. Pithecellobium dulce is regarded as one such plant which have remarkably wide range of therapeutic activities. This tree is originally native to the Americas and is now cultivated widely across India, particularly in the Andaman region. The tree composed multiple chemical constituents like alkaloids, glycosides, flavonoids, steroid saponins. The main compounds present in leaves reported include cyclitol, dulcitol, octacosanol, kampferol-3-rhamnoside and quercetin. The leaves of the plant have been used to manage fever, intestinal problems, infections, tooth ache and ear ache. Furthermore, it reveals the significant activity against the diabetes, diarrhea, inflammation, fungal infection, bacterial infection, oxidative stress, hyperlipidemia etc. It holds a significant position in traditional healing. supernatural fruit of the herbal medicine. The current review is intended to highlight the pharmacological & therapeutic significance of Pithecellobium dulce leaves from research literature evidence