Abstract: Depression is one of the most prevalent mental health disorders globally, with profound implications on individuals, families, and society. Despite advances in pharmacological and psychological treatments, relapse rates remain high, and stigma often prevents patients from seeking adequate support. Psycho-education has emerged as a vital nursing intervention to empower patients with depression by improving knowledge, promoting treatment adherence, enhancing coping skills, and reducing stigma. This article examines the role of psychoeducation in depression care from a nursing perspective. It highlights the principles, methods, and evidence-based outcomes of psychoeducational interventions in clinical and community settings. Nurses, as frontline providers, play a central role in delivering psychoeducation by fostering therapeutic relationships, enhancing health literacy, and supporting patient autonomy. Barriers such as cultural differences, stigma, and limited resources are discussed alongside strategies to improve implementation. Ultimately, psychoeducation not only improves patient outcomes but also strengthens the nurse-patient partnership, contributing to holistic and sustainable mental health care.