Abstract: Suicide is one of the most pressing public health concerns worldwide, claiming more than 700,000 lives annually and leaving families and communities with deep scars. Mental health professionals, especially nurses, are uniquely positioned to play a vital role in suicide prevention because of their continuous interaction with patients in diverse healthcare and community settings. This article explores the multifaceted role of nurses in suicide prevention, focusing on risk identification, protective factor reinforcement, effective communication, crisis intervention, follow-up care, and community advocacy. It emphasizes the necessity of evidence-based nursing interventions and interdisciplinary collaboration to address the complex biopsychosocial dimensions of suicide. Furthermore, the article examines challenges in nursing practice such as stigma, limited training, and resource constraints, while also highlighting opportunities for innovation through simulation-based education, telehealth, and community engagement. The discussion underscores that empowering nurses with knowledge, skills, and supportive systems can significantly reduce suicide rates and promote mental health resilience across populations.