Human Resource Management (HRM) plays pivotal role in shaping organization’s culture and practices. In Nigeria, HRM is challenged by multiple ethical concerns that impact employee relations, organization performance, and national development. This paper examines the major ethical issues inherent in HRM in Nigerian context including discrimination, exploitation, workplace harassment, and poor or none adherence to labour laws. The paper examines and analyses using contemporary literature, the causes of these issues namely: cultural norms and social expectations, economic factor, poor institutional frame work and inadequate and unstable HRM. Recommendations for best practices were suggested.