Objective: The aim of this study was to evaluate the efficacy of intravenous octreotide after sclerotherapy in the prevention of variceal bleeding. Study Design: A comparative / interventional study. Place and Duration: In the Gastroenterology Department Jinnah Hospital Lahore for one year duration from June 2017 to June 2018. Methods: Sixty consecutive patients (mean age: 47.48 ± 9.60 years) (26-65 years) with acute variceal bleeding were included in the study. There were Forty-two (70%) males and eighteen (30%) females. They were randomized into two equal groups. In the study group (group I), 24 hours after sclerotherapy, octreotide infusion (25 g / hour) was continued, while the control group received approximately the same amount of saline. Both groups were observed for the presence of early re-bleeding of varices for five days after sclerotherapy. Results: Re-bleeding was 23.3% in group I and 33.3% in group II (p> 0.05). The number of patients requiring blood transfusion was similar in both groups (p> 0.05). According to a general impression at the end of the study, 10% of the patients became unstable in group I and 36.7% in group II became unstable (p = 0.02). . Conclusion: After 24 hours of sclerotherapy, no significant effect was observed for the prevention of re-bleeding with the variants of octreotide infusion. However, at the end of the study, a general impression based on hemodynamic status revealed that patients were clinically more stable after an injection of octreotide after an injection sclerotherapy. Key words: sclerotherapy, variceal re-bleeding.