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ZENODO
Article . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
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AI-Driven risk prediction models for hypertensive emergencies in diabetic patients: validation in multi-ethnic cohorts

Authors: Khikmatova Madina; Sanoyev Baxtiyor; Ismatova Mexriniso; Abdullaeva Muslima; Alimova Iroda; Khudoykulov Erkin; Madina Bekchanova; +1 Authors

AI-Driven risk prediction models for hypertensive emergencies in diabetic patients: validation in multi-ethnic cohorts

Abstract

The study was undertaken to confirm artificial intelligence (AI) risk models of hypertensive emergencies among diabetic patients in multiethnic populations. The study was a multicenter historical cohort involving 24,718 diabetic and hypertensive patients from various ethnic groups (European, African, South Asian, Hispanic, East Asian, and Middle Eastern). The performances of three machine learning algorithms (XGBoost, neural network, and random forest) were contrasted with logistic regression. The outcomes showed that the XGBoost model, which recorded AUC values of 0.89 for Cohort B and 0.85 for Cohort B, was significantly better compared to standard models and had a high ability to identify evolving patterns such as systolic blood pressure fluctuation and kidney function changes. However, subgroup analyses revealed significant ethnic differences in model performance: sensitivity was lower in African-American (76.2%) compared to South Asian (88.1%) patients, and positive predictive value was 15% lower in Hispanics compared with East Asians. Additionally, poor calibration in high-risk groups (African-Americans) and the influence of social determinants of health on predictive accuracy were observed. These findings reaffirm the importance of validating models in every ethnic environment, including social variables, and developing dynamic calibration procedures to provide equitable and accurate treatment.

Keywords

Artificial intelligence risk prediction, hypertension severity, diabetes mellitus, multiethnic validation, algorithmic fairness

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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