The study examined the influence of organizational politics and school culture on teachers’ work commitment at senior high schools in the Bosomtwe District. The objectives of the study were to find out the kind of positive school culture available in senior high schools, assess the impact of organizational politics on the work commitment of senior high school teachers, find out the challenges faced by senior high school teachers due to organizational politics and school culture, and ascertain measures to improve organizational politics and school culture on work commitment of senior high school teachers. The descriptive research design with the quantitative approach was used for the study. The target population for study was 496. Simple random sampling technique was used to select 221 respondents for the study. The researchers used closed ended questionnaire as the research instrument to collect data for the study. The reliability test yielded Cronbach alpha of 0.82. Fostering commitment among staff and students, collaboration among teachers and effective communication among staff were some of the positive school culture available in the senior high schools involved in the study. Limited availability of teaching and learning resources fosters competition among teachers, the lack of clear policies and inconsistent enforcement of rules create room for favoritism, a school culture that tolerates favoritism, bias, and informal power struggles, limited availability of teaching and learning resources fosters competition among teachers were some of the factors to improve organizational politics. It is recommended, among other things that the Directors of Education and heads of senior high schools should ensure the presence of school culture that enhance work commitment of senior high school teachers in the study area.