The Deliverable 4.4 presents Guidelines (related to materials, techniques, approaches and collaborations) to implement novel breeding techniques and approaches in the Neglected and Underutilised Crops (NUCs) seed and breeding sector. The recommendations listed in this report have emerged from the work of the DIVINFOOD Living Labs (LLs) with minor cereals and legumes in various regions of Europe. The target audience for this report is stakeholders, including breeders, researchers, farmers and network facilitators interested in developing the seed and breeding sector of minor crops or open to explore alternative paths in their work in major crops. Although this report is based on the specific experiences of the DIVINFOOD LLs on advancing cultivation and use of Neglected and Underutilised Crops (NUCs), the guidelines presented can serve as reflection points for any network working on seeds with a specific interest in the overall sustainability of the food system.