Delving into the persistent impacts of colonialism within the sphere of modern science, here we explore some of the deep-seated disparities between the Global North and South with regards to the scientific enterprise. Central to this inequality are the hurdles of language and financial support. As such, this work discusses the often-overlooked obstacles that Global South scientists face, including the additional efforts non-native English speakers must invest in reading and publishing, their higher rejection rates, and the widespread neglect of publications in languages other than English. These challenges not only hinder the advancement of science but also deepen existing divides. Furthermore, we examine the double-edged sword of open-access requirements. While these policies democratize access to scientific knowledge, they can inadvertently exacerbate the North-South inequalities due to, for example, the prohibitive costs associated with open-access publishing—a financial burden that is often unmanageable for researchers with limited funding. This funding gap severely restricts the Global South’s scientific capabilities and impact, affectingeverything from conducting comprehensive research to attending scientific meetings. The culmination of these disparities not only diminishes the impact of Global South researchers in their fields but also traps them in a cycle of reduced funding and limited global networking opportunities. In addressing these complex issues, the contributions in this work highlight some of the most common and pronounced issues related to scientific inequalities, as well as suggesting possible ways of bridging this gap in order to reach a more equitable distribution of resources and recognition in the global scientific community.