Abstract: Cardiopulmonary Resuscitation (CPR) is a critical emergency intervention aimed at restoring circulatory flow and oxygenation during cardiac arrest. The American Heart Association (AHA) periodically updates CPR guidelines to improve survival rates and neurological outcomes, with the 2020 revisions emphasizing high-quality chest compressions, appropriate ventilation, automated external defibrillator (AED) use, and timely advanced life support. Nurses, as frontline responders, require up-to-date knowledge and skills to deliver effective resuscitation. B.Sc. Nursing students, particularly in their second year, are at a pivotal stage of integrating theory with clinical practice, making competency in CPR essential. This study evaluates the knowledge, attitude, and practice regarding the revised AHA CPR guidelines among second-year B.Sc. Nursing students at a selected nursing college in Indore. Findings will help identify gaps, inform targeted training programs, and enhance preparedness, ultimately contributing to improved patient outcomes in cardiac emergencies.