Aim: The aim of the present investigation is to prepare curcumin nanoparticles using thenano precipitation technique. The main objective is to regulate the drug release, maximisetherapeutic effectiveness.Methodology: The drug is incorporated into the polymer (such as Eudragit S 100 and ethylcellulose) by adjusting the drug-polymer concentrations and organic-aqueous ratios. Total 10formulations were prepared and % yield, % drug content, and in vitro drug release wereevaluated.Results: Out of all the formulations ,F3 was considered to be the best formulation withminimum particle size of 219.4nm, drug content of 99%, %entrapment efficiency of 98.23%,zeta potential value (-47.1mv), In vitro drug release of 46.11% which was sustained up to 12hours. The drug release kinetic study of the best formulation was studied.Conclusion: F3 was considered for the determination of anti-cancer activity in vitro in MCF-7 Breast cancer cell line by MTT assay. The results indicated that the prepared formulationdemonstrated anti- cancer activity with an IC50 value of 38.5μg.