Abstract: Background: Barrett’s esophagus (BE) is the byproduct of chronic gastroesophageal reflux disease (GERD) that can cause metaplastic changes of the distal esophageal wall. The primary objective of the study aims to evaluate the efficacy and safety of Hybrid APC in the ablation of Barrett’s esophagus. The secondary objective aims to evaluate the safety and efficacy of HybridAPC in patients with refractory Barrett’s esophagus who have failed radiofrequency ablation (RFA). Methods: This retrospective case series included 27 patients with Barrett’s esophagus who underwent Hybrid APC. Data collected included patient demographics, procedural details, clinical outcomes, adverse events, and follow-up. Results: Hybrid APC ablation was successful in all 27 patients involved in the study. There were no immediate complications following the procedure. Patients were followed up at 8-12 week intervals. Conclusion: Hybrid APC is a relatively novel technique for the ablation of Barrett’s esophagus. It appears to be safe and effective treatment in patients with Barrett’s esophagus and those who underwent prior unsuccessful RFA