Endometriosis is a chronic inflammatory condition predominantly affecting reproductive-aged women, characterized by ectopic endometrial tissue and significant symptom burden, including chronic pelvic pain, dysmenorrhea, and dyspareunia. While traditionally considered a gynecological disorder, emerging evidence highlights its systemic impact involving gastrointestinal, immune, endocrine, and neurological systems, where stusy was cross-sectional for evaluated 90 women aged 18–45 with confirmed endometriosis across multiple domains including chronic pain severity, mental health comorbidities, systemic manifestations, and quality of life. Results demonstrated high prevalence of debilitating symptoms: chronic pelvic pain (86.7%, mean VAS 7.2), dysmenorrhea (94.4%, mean VAS 8.1), and substantial mental health burden with 53.3% screened positive for depression and 57.8% for anxiety as well as Gastrointestinal symptoms such as irritable bowel syndrome were noted in nearly half of patients. Fatigue and sleep disturbances were highly prevalent, adversely affecting daily functioning as measured by SF-36 scores furthermore Autoimmune and endocrine comorbidities, including hypothyroidism and fibromyalgia, were also reported. Significant correlations were found between pain severity and depression, anxiety, and poor sleep quality, underscoring the multifaceted nature of endometriosis-related morbidity where finally Findings emphasize the necessity of a multidisciplinary management approach integrating gynecologic, psychological, and pain therapies and Early diagnosis, comprehensive assessment, and holistic treatment strategies are essential to improve health outcomes and quality of life in endometriosis patients, moving beyond symptom-focused care towards personalized, systemic management.