This study examined the relationship between strategic entrepreneurship and operational performance of indigenous oilfield services firms in South-South States of Nigeria. The underpinning theories of the study were dynamic capabilities theory and innovation theory. The study adopted descriptive cross-sectional survey research design at organizational unit of analysis with five-points Likert scale questionnaire for data collection. The population of the study was 1827 indigenous oilfield services firms in South-South States, Nigeria with sample size of 328 determined by Taro Yamane’s formula and Bowley’s formula for proportional allocation of respondent firms. The reliability was determined by Cronbach’s Alpha while construct validity was with Pearson’s r, factor analysis, Kaiser-Meyer-Olkin (KMO) and Bartlett’s Test of Sphericity. The data analysis were descriptive and inferential statistics in Microsoft Excel Software Package version 2016 and International Business Machine (IBM) Statistical Package for the Social Sciences (SPSS) version 29 software application tools respectively. Pearson Product Moment Correlation Coefficient (PPMCC) techniques was used to test the hypotheses. The results showed that strategic entrepreneurship had positive and significant relationship with operational performance of indigenous oilfield services firms in South-South States, Nigeria. This study provided empirical evidence of positive and significant relationship between strategic entrepreneurship and operational performance of indigenous oilfield services firms.