The subgenus Stegomyia Theobald of the genus Aedes Meigen in the Afrotropical Region is characterized. Eleven species groups are recognized and diagnosed. The taxonomy, distribution, bionomics and medical importance of the species of the region are discussed and summarized. Keys and illustrations are provided for the identification of the 11 species groups and 59 species and subspecies known to occur in this region. Information on the present status of the species of the African Stegomyia is summarized. Six new species: Aedes ealaensis, ethiopiensis, gandaensis, hogsbackensis, mpusiensis and sampi are recognized. Aedes blacklocki Evans is restored to specific status. One subspecies, denderensis Wolfs is elevated to specific status.