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ZENODO
Article . 2015
License: CC 0
Data sources: Datacite
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ZENODO
Article . 2015
License: CC 0
Data sources: ZENODO
Claim

A Protocol For In Vivo Magnetisation Of Mice Colon And Application Of Physiological Mechanical Deformations To Study Mechanotransduction In Tumour Growth Pressure

descriptionPublicationkeyboard_double_arrow_right Article 24 Mar 2015Publisher:Zenodo
Authors: sprotocols;

doi: 10.5281/zenodo.16315

A Protocol For In Vivo Magnetisation Of Mice Colon And Application Of Physiological Mechanical Deformations To Study Mechanotransduction In Tumour Growth Pressure

Abstract

This protocol is an innovative method developed to study mechanical pressure in vivo, by subcutaneously inserting a dorsal magnet close to the mouse colon. The implanted magnet generates a magnetic force on ultra-magnetic liposomes (UML), stabilized in the mesenchymal cells connective tissue surrounding colonic crypts after intravenous injection. The pressure induced magnetically quantitatively mimicks in vivo the endogenous early tumour growth stress in the order of 1200 Pa without affecting tissue stiffness, as monitored by acoustic strain imaging and shear wave elastography.

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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