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ZENODO
Article . 2015
License: CC 0
Data sources: Datacite
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ZENODO
Article . 2015
License: CC 0
Data sources: ZENODO
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Preparation Of Aptamer-Functionalized Lipid Nanoparticles (Lnps) Encapsulating Sirnas

descriptionPublicationkeyboard_double_arrow_right Article 24 Mar 2015Publisher:Zenodo
Authors: sprotocols;

doi: 10.5281/zenodo.16314

Preparation Of Aptamer-Functionalized Lipid Nanoparticles (Lnps) Encapsulating Sirnas

Abstract

Briefly, lipid nanoparticles were prepared by spontaneous vesicle formation after a lipid-ethanol solution was slowly injected into siRNA buffer solution and then dialyzed. The 3’ thiol-modified aptamers were first activated and then conjugated to DSPE-PEG2000-Mal to form aptamer-PEG2000-DSPE. Finally, aptamer-PEG2000-DSPE in the form of micelles was inserted into the surface of the LNPs.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
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