Recently the steady tendency to increase in volumes of transportation, oil was outlined. Thus, developments new or optimization of the applied technologies of transportation of oil taking into account their rheological properties and operational characteristics of pipelines are necessary for the solution of a task of increase in volume of pumping of crude oil. Because of relevance of a problem, results of the pilot studies mixed crude oil by physical and chemical methods are of a great interest. The researches conducted by us have shown that when mixing crude oil it is necessary to consider a factor of interference of structures crude oil for the purpose of an assessment inadmissible and optimum concentration of separate components.