The goal of this deliverable is to present a set of initial policy recommendations under the collaborative efforts from the 6 projects within the "Prevention and early detection" cluster of the Mission Cancer initiative, based on the Research and Innovation strand. This policy brief is intended to amplify the overall impact on the Mission Cancer's aspirational objective of enhancing the lives of over 3 million individuals by 2030. Firstly, the main challenges each project faced in community, national and EU-level are presented, alongside with identified opportunities. Following by the outcome of our workshop in Research & Innovation during our 1st annual meeting in Vienna. Table 3 introduces the policy recommendations each project formulate based on their findings so far and finally a list of our first common policy recommendations as a cluster are presented.