Abstract Oppositional Defiant Disorder (ODD) is a behavioral condition that poses significant challenges for parents and families. While conventional approaches attribute ODD to genetic predispositions, neurobiological factors, and adverse life experiences, this study introduces a spiritual dimension grounded in Buddhist teachings. By analyzing seven specific cases, it examines the role of karmic influences and spirit attachment in the manifestation of ODD symptoms. The findings suggest that unresolved karmic debts and spiritual disturbances may play a significant role in the disorder’s development. The study underscores the potential of Dharma practices, such as reciting Buddhist scriptures and addressing karmic influences, in alleviating symptoms of ODD, including rebellious behavior, emotional instability, and comorbid conditions like autism and bipolar disorder. This research highlights the importance of expanding the understanding of ODD’s etiology by integrating spiritual perspectives with scientific approaches. It advocates for a holistic treatment model that combines the wisdom of Dharma with conventional therapies, offering renewed hope for individuals with ODD and their families. Finally, it is suggested to use "spirit oppression" instead of "sleep paralysis" to more accurately reflect the true nature of this phenomenon.