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ZENODO
Dataset . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
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SingleBrain: Single-nucleus Trans Expression QTL Meta-analysis Summary Statistics across Multiple Human Brain Cohorts

Authors: Jang, Beomjin; Hong, Won Hee; Raj, Towfique;

SingleBrain: Single-nucleus Trans Expression QTL Meta-analysis Summary Statistics across Multiple Human Brain Cohorts

Abstract

https://github.com/RajLabMSSM/SingleBrain Bonferroni significant association summary statistics for trans-eQTLs mapped in a meta-analysis across multiple human brain single-nucleus RNA seq cohorts, as part of the "SingleBrain" project. Sample size = 983 European ancestry donors from 757 unique donors 4 cohorts (Fujita et al., Mathys et al., Bryois et al., Gabitto et al.) meta-analyzed using the linear mixed model random-effects meta-analysis software mmQTL (PMID: 35058635). Number of tested SNPs = 265,814 Bonferroni threshold = 0.05/(#genesTested x #variantsTested) Each file has the following naming convention: {Cell type}_trans_eqtl_peak_1_sig_assoc.tsv.gz References The following reference was used for mapping phenotypes: 1. GENCODE - GENCODE v38 comprehensive transcripts (https://www.gencodegenes.org/human/release_38.html) Cell type The following brain 6 major cell types were tested for genetic association: Ast: astrocytes Ext: excitatory neurons IN: inhibitory neurons MG: microglia OD: oligodendrocytes OPC: oligodendrocyte progenitor cell All phenotype matrices were scaled and centered and then quantile normalized. Data dictionary feature: the phenotype being tested variant_id: the genetic variant being tested chr: chromosome pos: position (hg38) ref: reference allele alt: alternate allele fixed_beta: Fixed effect meta-analysis estimate of the beta fixed_sd: Fixed effect meta-analysis standard error of the beta fixed_z: Fixed effect meta-analysis Z-score Fixed_P: Fixed effect meta-analysis P-value Random_Z: Random effect meta-analysis Z-score Random_P: Random effect meta-analysis P-value cis_feature: cross-mappable gene pair with feature crossmap: cross-mappable gene pairs estimated using Saha et al.[PMID: 30613398] are filtered less than 5.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average